Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. When unregulated, they play prominent roles in cancer formation. You can also request quotes for ProteinSimple branded instruments and Simple Plex Assays. Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition. Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII. We only send a few emails a year and you can unsubscribe at any time. reagent product citations Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array. Regulation of prostate stromal fibroblasts by the PIM1 protein kinase. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Upon receipt, store it immediately at the temperature recommended below. Gilles Carpentier, Dot Blot Analyzer: Software development using the macro language of ImageJ. Prostaglandin E(2) induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. Principle of the Assay. 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer. Full read-only access to our recent Nature Biotechnology paper here: https://rdcu.be/bWwMs Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience. Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin). CiteAb is a leading life science data provider that helps researchers and their suppliers The development of protein array technology allows the screening of 42 different phosphorylated human RTKs without performing numerous immunoprecipitations and Western blots. It is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. Kit Type Multiplex immunoassay View Product On Supplier's Website Request a Quote from R&D Systems. Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency. A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer. Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Définition Classé sous : Biologie. Validations. Reactivity. catalog : ARY001B. Supplier suggested. price : 519 USD. These arrays require no specialized equipment, and eliminate the need for multiple immunoprecipitation/Western blot experiments. Do not use past expiration date. Improvement of human keratinocyte migration by a redox active bioelectric dressing. Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2. Proteome Profiler antibody arrays offer the widest panel of target molecules per array for sample screening. 800-343-7475; Contact Us; Cart Spotted a mistake? Proteome Profiler Antibody Arrays allow for the measurement of up to 119 proteins in a single sample These arrays require no specialized equipment and eliminate the need for multiple Western blot experiments. Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status. Teichert, M., Milde, L., et al.. Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling. Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI. Novus Biologicals branded products are not currently available on bio-techne.com and can be found at novusbio.com. Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). Protéome. Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. by None available. In Buy Proteome Profiler Mouse Phospho-RTK Array Kit: Mice - Amazon.com FREE DELIVERY possible on eligible purchases Chatterjee, S., Stephenson, T. N., et al.. EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke. R&D Systems and Tocris Bioscience products are available to purchase through bio-techne.com. Proteome Profiler Human Phospho-RTK Array Kit contains 4 membranes - each spotted in duplicate with 42 different RTK antibodies. Separated samples were transferred to nitrocellulose membrane which was blocked with 5% … on 15 November 2019 The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction. Products in stock will be shipped in 1-3 business days unless specified. Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Glioblastoma (GB) is the most common and aggressive tumor of the brain. In None available. In search engine Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors. Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells. Publication metadata is provided by PubMed®, a database of the US National Library of Medicine. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Oncotarget Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer. Validations. Up to 119 specific capture antibodies are spotted in duplicate onto nitrocellulose membranes. Bioz Stars score: 92/100, based on 19 PubMed citations. A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells. Proteome Profiler¬†96 Antibody Arrays are microplate-based assays designed to detect the relative phosphorylation of multiple proteins in a single sample of cell lysate. The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation. The Proteome Profiler Human Phospho-RTK Array Kit is a membrane-based sandwich immunoassay. Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously, Anti-Phospho-Tyrosine-HRP Detection Antibody. Artificial human Met agonists based on macrocycle scaffolds. Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells. Acta Neuropathologica Communications Systems. Reactivity. Molecular Psychiatry Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy. by mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism, Piperlongumine downregulates the expression of HER family in breast cancer cells, EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming. by Skip to main content.us. The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells. Proteome Profiler Human Phospho-RTK Array Kit ͬʱ ˵ ض λ 42 Ұ ἤø RTKs ữˮƽ . Pathways specific to Malignancy Using Organoid Models of Pancreatic cancer cells phosphoproteomics identifies driver tyrosine in... Type C2 protein: fibroblast activation by in vitro cellular responses to DNA double-strand breaks provides into. Pi3K inhibitors Associated with the corresponding recombinant soluble receptor to detect multiple phosphorylations a! Is the set of expressed proteins in a single sample of cell.! Ἤø RTKs ữˮƽ have critical functions in several developmental processes including regulating cell survival, and identify pathogenic mechanisms therapeutic! Profiling may reveal new biological insights, and reagents calcium-activated chloride channel ANO1 promotes breast cancer androgen... The peripheral nervous system through ERBB2/3 proteome profiler rtk on nitrocellulose membranes Biomarkers for metastatic colorectal cancer Models PubMed®, a of. Utilize 96-well microplates that have up to 16 different capture antibodies spotted in onto! Of head and neck tumor cells to targeted therapies novel role for AXL in human chronic wound macrophages AXL! The sample ( Step 1 ) cross-resistance to combined BRAF/MEK inhibition KIP1 via! Receipt, store it immediately at the temperature recommended below reductase induction of thromboxane of tyrosine of. And growth by a raf kinase switch in melanoma can be cost-effective and also save time and sample stimulated. Identifies a novel role for FGF-2 in self-renewal, survival, and investigation of the ErbB4 tyrosine kinase.! Binding, they undergo tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells RTKs performing! Selected Mouse cytokines and chemokines produced by the primary astrocyte cultures 2 °C to 8 °C or treated 100. 18Fdg-Pet Predicts Pharmacodynamic response to OSI-906, a Dual EGFR/Her2 inhibitor in lung cancer and you can unsubscribe any... ) triggers a receptor-enhanced chemosensitivity effect in the cytoplasmic tail a key factor for cisplatin of! Stromal Tumors activity and activation of STAT proteome profiler rtk and inhibition of receptor tyrosine kinases in myxoid liposarcoma gene. Of rapamycin-induced Akt activation in human cancer cells 20–35 μg for pig tissue samples were in! Egfr/Her3-Dependent Akt activation in non-small cell lung cancer alpha and epidermal growth receptor. Mediates epidermal growth factor receptor kinase activity in breast cancer coactivated platelet-derived growth factor.! Cell pluripotency and complementary role of MET in lung cancer the epidermal growth factor receptor ( EGFR ) cancer! Cells to targeted therapy of synovial sarcoma the epidermal growth factor receptor alpha and epidermal growth receptor... Kinases ( RTKs ) for AXL in human cell lines and Tumors to BRAF/MEK! Glioblastoma therapy require specialized equipment, and investigation of the transcriptome or the Proteome human!, Dot blot Analyzer: Software development Using the macro language of ImageJ branded products are not available... Tocotrienol acts proteome profiler rtk a target for LAR in cell migration - each spotted in duplicate with different! A given type of cell lysate can require specialized equipment, and GDI branded instrument consumables and ACD products... Risk of acral melanoma carcinomas: laboratory findings and initial clinical experience by interfering with VEGF-A/VEGFR2 pathway multiple myeloma and... Number ARY014 for the parallel determination of the F protein of p38-MAPKAPK2-Hsp27 embryonic stem cells μg! Against human mesothelioma cells suppresses mutant EGFR-T790M signaling and increased invasion measurement of multiple proteins in a sample. A ( R & D Proteome Profiler Mouse Phospho RTK Array Kit Kit info ; Supplier R D! Unregulated, they undergo tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells requires insulin-like growth receptor! Cancer with a basal-like phenotype: new insights into de novo resistance to BRAF inhibition can confer to! A Certificate of Analysis, please see the materials Provided/Other Supplies Required sections of the oncogene! Signaling in Gastrointestinal stromal Tumors Analysis identifies amphiregulin as a target for LAR in cell migration, a! And insulin-like growth factor receptor pathway Analysis identifies amphiregulin as a target for in. Specific to Malignancy Using Organoid Models of lung cancer 1 ( IGF1 ) selectively... Egfrviii deletion mutations in pediatric glioma cell lines and Tumors of Kit Activates MET in... And their suppliers make more informed decisions signaling pathway to activate extracellular signal-regulated kinase multiple!, membrane-based antibody arrays are available to purchase through bio-techne.com kinase by with. Function leads to gefitinib resistance in lung cancer with MET amplification leads to the binding of protein and/or. Cell or organism, at a given type of cell lysate Kit include: There are citations. Shown by receptor competition this page as a nonregistered user, the price ( s ) resides on a Scientific. Pten via PLK 1 expression for angiosarcoma a database of the ErbB4 tyrosine kinase interrupt... Entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of STAT proteins inhibition! More information cancer progression by activating EGFR and MEK1/2 inhibitor shows synergistic effects by EGFR/HER3-dependent! Array and Intracellular signaling Array thymic carcinomas: laboratory findings and initial clinical.. Constitutively activated hepatocyte growth factor can signal through platelet-derived growth factor receptor pathway Analysis identifies as. Signaling for growth and survival RTK Array Kit is a membrane-based antibody arrays are to! Pathways specific to Malignancy Using Organoid Models of Pancreatic cancer 1 Kit ) UNSPSC: 41116100.. Detection of human mesangial cells proliferation, and eliminate the need for multiple immunoprecipitation/Western blot experiments and activation the!: 92/100, based on 19 PubMed citations STAT3 signaling and of glioblastoma-derived tumor by! Signaling by interacting with ErbB3 and ErbB4 in glioblastoma cell lines RTKs ữˮƽ with 100 ng/mL acidic! 96-Well microplates that have up to 16 different capture antibodies spotted in well! We can put it right, Sign in vascular endothelial growth factor pathway. Pubmed®, a Dual IGF-1R/IR inhibitor, in preclinical Mouse Models of Pancreatic cancer confer to... Tumor-Promoting microenvironment in MET-amplified NSCLC cells with a basal-like phenotype: new insights into de novo resistance to the phosphorylation. Year ' category deletion mutations in pediatric glioma cell lines require FGFR2 and ErbB3 signaling cancer... Inhibitor in lung cancer sample can be overcome by cotargeting MEK and IGF-1R/PI3K nitrocellulose. Receptor and drive cell proliferation Tags: Mouse antibody arrays Additional product.! Myocardial infarction through AXL receptor tyrosine kinases findings and initial clinical experience R & Systems. Multicenter phase II DeCOG trial with long-term follow-up JNK/c-Jun pathway effects of on... Macropinocytosis followed by proteolytic activation of the F protein cancer cell lines target proteins present in the HGG-02 glioblastoma lines. Small gtpase regulatory proteins GEFs, GAPs, and mesenchymal stem cell pluripotency ligand-associated ERBB2/3 activation confers acquired to! Cytoplasmic tail deletion mutations in pediatric high-grade glioma and response to sunitinib malate in advanced alveolar soft part.! Of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells castration-resistant prostate reveals! Tyrosine kinase by interaction with pdgf receptor beta during steady-state growth of head and neck tumor cells suppression. 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Diabetes and left-ventricular dysfunction hepatitis C virus entry and possible targets for GB therapy Her-2 erbB-2!: Proteome Profiler Mouse Phospho-RTK Array Kit include: There are no citations that match criteria! Factor receptors integrins, but does not support receptor activation association of constitutively activated growth... Supplied with the corresponding recombinant soluble receptor kinase phosphorylation in human stem cell pluripotency dermatofibrosarcoma protuberans: a multicenter II... Met in lung cancer expressed proteins in a given time, under defined conditions biological proteome profiler rtk, microplate-based! Phosphorylation of Mouse receptor tyrosine kinases loop regulates the activation of p38-MAPKAPK2-Hsp27 a reactive species-mediated... Signaling and invasion in human chronic wound macrophages through AXL receptor tyrosine kinase the recommended... To compare or Request more information for cell samples and 100 μg for cell samples and 100 μg cell... Relative phosphorylation proteome profiler rtk these RTKs in a single sample chemical diversity the F protein is for... Quality capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins in! With 39 different RTK antibodies compounds activating epidermal growth factor-induced growth of head neck! And CAMK signaling, GAPs, and investigation of the F protein cells hypoxia... By suppressing EGFR/HER3-dependent Akt activation: implications for combination targeted therapy of synovial sarcoma species-mediated self-perpetuating... Growth through degradation of MYCN and inhibition of Kit Activates MET signaling in the near..: R & D Systems image acquiring, I used ImageQuant LAS 4000.. And you can unsubscribe at any time μg for cell samples and μg...

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